Product description

Size

10 mg

Product code

AM010

Human LR³ insulin-like Growth Factor-I (LR³IGF-I) is an 83 amino acid analogue of IGF-I comprising the complete human IGF-I sequence with the substitution of an Arginine for the Glutamine at position 3, plus a 13 amino acid extension peptide at the N-terminus.

Human LR³IGF-I is more potent than IGF-I in vitro and in vivo. This increased potency is due to reduced binding of LR³IGF-I to most of the IGF binding proteins which modify the biological actions of IGF-I. Human LR³IGF-I binds to the type 1 IGF receptor with similar affinity to wild type IGF-I.

LR³IGF-I was developed by GroPep specifically for supplementation of mammalian cell culture to support the survival and proliferation of cells. It is engineered to have a higher biological potency than native IGF-I or IGF-II and has several advantages over recombinant insulin. Supplementation of cell cultures with LR³IGF-I at a much lower concentration results in equivalent or better productivity than supplementation with standard concentrations of insulin. LR³IGF-I is better able to stimulate the type I IGF receptor and thus induce a higher level of activation of intracellular signalling molecules which are responsible for promoting cell survival by inhibition of apoptosis.

Media grade LR³IGF-I is a high quality product for use in commercial cell culture.

It can also be used as a research reagent at an economical cost to enable studies where higher quantities of peptide are required.

Fact sheets

Human LR3 IGF-I (Media Grade) specifications

Human LR3 IGF-1 SDS

Related products

• Human [Arg3] IGF-I (Receptor Grade)
• Human LR3 IGF-I (Media Grade)
• Human IGF-I (Media Grade)
• Human LR3 IGF-I ELISA

自1990年以来，GroPep Bioreagents便已向大学，研究机构，生物技术和制药公司的研究人员开发，制造和销售生长因子，抗体和相关蛋白试剂。

我们的任务是在准确和可靠的技术建议的支持下，为科学家提供高质量的试剂。

我们科学人员的强大研究背景和经验是我们为客户提供“动手”建议的关键。

我们了解我们的产品并倾听您的需求。

我们通过会议赞助和向会员提供折扣来支持IGF协会